1-(tert-Butyloxycarbonyl-methyl)-1H-indole-2-carboxylic acid ethyl ester → 1-(carboxy-methyl)-1H-indole-2-carboxylic ethyl ester

Participants

Reaction Conditions

Reaction Steps

A solution of ethyl 1-(2-tert-butoxy-2-oxoethyl)-1H-indole-2-carboxylate (4.64 g) is 25 mL of formic acid (88%) was heated at 100° C. for 1 hr. TLC showed that the reaction was complete. The solvent was removed by evaporation and the residue was triturated with water and filtered to collect the solid. The beige solid was air dried overnight to afford 3.78 g of the desired product.

Provenance & Evidence