HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cesium carbonate → HCID 89407762, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Ethane, 1-fluoro-2-iodo- | HCID 69804 | — |
| Reactant | HCID 71258961 | HCID 71258961 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 89407762 | HCID 89407762 | 73.2% |
Reaction Steps
To methyl 3-[(tert-butoxycarbonyl)amino]-3-(3-hydroxyphenyl)propanoate (4.46 g, 20 mmol) in THF was added cesium carbonate (9.84 g, 30 mmol) and 1-fluoro-2-iodoethane (5 g, 30 mmol) and the mixture was stirred for 9 hours. After filtration the filtrate was concentrated in vacuum to yield 5.0 g of methyl 3-[(tert-butoxycarbonyl)amino]-3-[3-(2-fluoroethoxy)phenyl)propanoate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09345793B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-aa2dd54df00e41f1b7928878ca8227aa |
| Source note | uspto-grants-2016_05 |