反应详情

温度

0 °C

5.298 g (29.24 mmol) commercial 3-amino-3-(4-hydroxyphenyl)propionic acid were suspended in 136 ml methanol, the mixture cooled to 0° C. and 3.20 ml (43.86 mmol) thionyl chloride were slowly added. The mixture was stirred at room temperature for 20 hours and concentrated. The residue was treated with saturated sodium hydrogen carbonate solution and extracted with dichloromethane and dichloromethane/2-propanol 8:2. The organic part was concentrated to give 5.09 g (80%) 3-amino-3-(4-hydroxyphenyl)propionic acid methyl ester.

1. concentrationconcentrated
2. additionThe residue was treated with saturated sodium hydrogen carbonate solution
3. extractionextracted with dichloromethane and dichloromethane/2-propanol 8:2
4. concentrationThe organic part was concentrated