3-Methoxybutan-1-amine → HCID 178495073, compound

HRID 526503Notes

Reaction equation

HRID 526503 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[CH:5][CH:4]=1)#[N:2].[CH3:24][O:25][CH:26]([CH3:30])[CH2:27][CH2:28][NH2:29]>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([NH:29][CH2:28][CH2:27][CH:26]([O:25][CH3:24])[CH3:30])=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 222732153-Methoxybutan-1-amineHCID 178509615HCID 178509615, compound

Product 1

HCID 178495073HCID 178495073, compound

Procedure

The title compound was prepared in a manner similar to Example 112 using 6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 3-methoxybutan-1-amine. 1H NMR (400 MHz, DMSO-d6) δ ppm 1.05 (d, J=6.32 Hz, 3H) 1.52-1.70 (m, 2H) 3.17 (s, 3H) 3.26-3.36 (m, 3H) 7.72 (d, J=8.59 Hz, 2H) 8.07 (d, J=6.57 Hz, 2H) 8.27-8.50 (m, 2H) 8.61 (t, J=5.43 Hz, 2H) 8.76-8.96 (m, 1H) 13.46 (br. s., 1H). MS m/z [M+H]+ 392.1.

Sources & evidence

ORD record
ord-ca2655d5ee8948ae9d6f8b33cfda416c
Source dataset
uspto-grants-2016_05
Patent number
US09345713B2

Reaction notes

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