1-(2-Methoxyethyl)cyclopropanamine hydrochloride → HCID 178494835, compound

HRID 526509Notes

Reaction equation

HRID 526509 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([O:24][CH3:25])[CH:4]=1)#[N:2].[CH3:26][O:27][CH2:28][CH2:29][C:30]1([NH2:33])[CH2:32][CH2:31]1>>[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([NH:33][C:30]4([CH2:29][CH2:28][O:27][CH3:26])[CH2:32][CH2:31]4)=[O:21])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([O:24][CH3:25])[CH:4]=1)#[N:2]

Participants

3

Reactant 2

HCID 626773661-(2-Methoxyethyl)cyclopropanamine hydrochlorideHCID 178492256HCID 178492256, compound

Product 1

HCID 178494835HCID 178494835, compound

Procedure

The title compound was prepared in a manner similar to Example 159 using 6-(4-(4-cyano-2-methoxyphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 1-(2-methoxyethyl)cyclopropanamine. 1H NMR (400 MHz, DMSO-d6) δ 0.58-0.74 (m, 4H) 1.80 (t, J=6.9 Hz, 2H) 3.14 (s, 4H) 3.39 (t, J=7.1 Hz, 2H) 3.89 (s, 3H) 7.32-7.44 (m, 2H) 8.27-8.35 (m, 2H) 8.42 (d, J=8.8 Hz, 1H) 8.57 (d, J=7.6 Hz, 1H) 8.76 (s, 1H) 8.80 (d, J=1.8 Hz, 1H). MS m/z [M+H]+ 434.5.

Sources & evidence

ORD record
ord-04fe0c583f644ba9bddaac5836049d5e
Source dataset
uspto-grants-2016_05
Patent number
US09345713B2

Reaction notes

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