HCID 18770857, compound → HCID 178422210, compound

HRID 526596Notes

Reaction equation

HRID 526596 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([OH:21])=O)=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[C:4]=1[F:25])#[N:2].[CH3:26][N:27]1[CH2:34][CH2:33][NH:32][CH2:31][C:28]21[CH2:30][CH2:29]2>>[F:25][C:4]1[C:5]([CH3:24])=[C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([N:32]4[CH2:31][C:28]5([CH2:30][CH2:29]5)[N:27]([CH3:26])[CH2:34][CH2:33]4)=[O:21])=[CH:17][N:16]=3)[C:13]=2[OH:14])[CH:7]=[CH:8][C:3]=1[C:1]#[N:2]

Participants

3

Reactant 2

HCID 18770857HCID 18770857, compoundHCID 178422218HCID 178422218, compound

Product 1

HCID 178422210HCID 178422210, compound

Procedure

The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 4-methyl-4,7-diazaspiro[2.5]octane. 1H NMR (400 MHz, DMSO-d6) δ ppm 0.58-1.34 (m, 4H) 2.33 (d, J=2.27 Hz, 3H) 2.91 (s, 3H) 3.31-3.85 (m, 6H) 7.62 (d, J=7.83 Hz, 1H) 7.70-7.78 (m, 1H) 7.82-8.75 (m, 4H). ESI-MS m/z [M+H]+ 447.3.

Sources & evidence

ORD record
ord-23b13d3243544e28960ff272a56eac86
Source dataset
uspto-grants-2016_05
Patent number
US09345713B2

Reaction notes

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