2-Methyl-2,6-diaza-spiro[3.3]heptane dihydrochloride → HCID 178422198, compound

HRID 526613Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19](O)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])=[C:5]([CH3:24])[C:4]=1[F:25])#[N:2].Cl.Cl.[CH3:28][N:29]1[CH2:32][C:31]2([CH2:35][NH:34][CH2:33]2)[CH2:30]1>>[F:25][C:4]1[C:5]([CH3:24])=[C:6]([C:9]2[CH:10]=[N:11][N:12]([C:15]3[CH:23]=[CH:22][C:18]([C:19]([N:34]4[CH2:35][C:31]5([CH2:32][N:29]([CH3:28])[CH2:30]5)[CH2:33]4)=[O:20])=[CH:17][N:16]=3)[C:13]=2[OH:14])[CH:7]=[CH:8][C:3]=1[C:1]#[N:2]

Participants

Reactant 2

HCID 863464762-Methyl-2,6-diaza-spiro[3.3]heptane dihydrochloride

HCID 178422218HCID 178422218, compound

Product 1

HCID 178422198HCID 178422198, compound

Procedure

The title compound was prepared in a manner similar to Example 301 using 6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1H-pyrazol-1-yl)nicotinic acid and 2-methyl-2,6-diazaspiro[3.3]heptane dihydrochloride. 1H NMR (400 MHz, DMSO-d6) δ ppm 2.33 (d, J=2.27 Hz, 3H) 2.80 (d, J=4.55 Hz, 3H) 3.94-4.67 (m, 8H) 7.61 (d, J=8.08 Hz, 1H) 7.69-7.78 (m, 1H) 8.16-8.29 (m, 2H) 8.42 (d, J=8.59 Hz, 1H) 8.69 (br. s., 1H). ESI-MS m/z [M+H]+ 433.3.

Sources & evidence

ORD record: ord-e149a0c0d3a845659c69b9c5eb559bf6
Source dataset: uspto-grants-2016_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09345713B2

Reaction notes

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