Bromine → HCID 89486588, compound

Participants

Reaction Steps

The intermediate, 4-carbonylpentyl benzoate (72 mmol), was dissolved in 75 ml dichloromethane. The temperature of the system was maintained below 5° C., bromine (3.7 ml, 72 mmol) was then slowly added dropwise. After the addition was completed, the stirring was maintained for half an hour, until the color of the reaction system disappears. The product was then washed with water, dried with anhydrous magnesium sulfate, and concentrated, to obtain the intermediate, i.e. 3-bromo-4-carbonylpentyl benzoate, which was directly applied in the next step without further purification.

Provenance & Evidence