Boron trifluoride → HCID 21954468, compound

Participants

Reaction Steps

In a 50 mL four-necked flask, 0.5 g of α,α,β-trimethyl-β-methacryloyloxymethyl-β-propiolactone was put, and dissolved in 10 g of ethyl acetate, and a stirrer, a thermometer and a Dimroth cooling tube were connected thereto. Further, 5 mol % of diethyl ether complex of boron trifluoride was added thereto based on the substrate, and 5 mg of p-methoxyphenol was added thereto, and while solution temperature was kept at 30° C., the resulting mixture was stirred. After the mixture was stirred for 2 hours, the resulting reaction mixture was washed with a 10% sodium carbonate aqueous solution and saturated brine, and dried over magnesium sulfate. After separation by filtration, the solvent was distilled off using an evaporator. A quantitative isomerization reaction to crude α,α,β-trimethyl-β-methacryloyloxy-γ-butyrolactone represented by formula (9) was confirmed. FIG. 2 shows an NMR measurement chart.

Provenance & Evidence