Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Benzylamine | HCID 7504 | — |
| Reactant | Citalopram Hydrobromide | HCID 77995 | — |
| Product | HCID 178483386 | HCID 178483386 | 19% |
Reaction Steps
Using 250 mg of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile hydrobromide (citalopram HBr) and benzylamine (1.2 equiv) gave, after heating at 80° C. for 14 h, title product (72 mg, 19% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09346777B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-3c7e2bb821384e6bb12e091912f90ffb |
|---|
| Source note | uspto-grants-2016_05 |
|---|
