HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 526809Generated: October 26, 2026
Morpholine → 1-[1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-yl]-1-(morpholin-4-yl)methan-imine
https://huagongshe.com/reaction/526809
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Citalopram Hydrobromide | HCID 77995 | — |
| Product | 1-[1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-yl]-1-(morpholin-4-yl)methan-imine | HCID 117844333 | 15% |
Reaction Steps
Using 400 mg of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile hydrobromide (citalopram HBr) and morpholine (1.5 equiv) gave, after heating at 80° C. for 28 h, title product (75 mg, 15% yield) as a white solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09346777B2 |
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| Source dataset | uspto-grants-2016_05 |
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| ORD ID | ord-5328bf1cbf554f3293617a36c3948dc9 |
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| Source note | uspto-grants-2016_05 |
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