反应详情

Potassium hydroxide (15.6 g, 0.28 mol), 15 ml of distilled water and 50 ml of heptane are added to a round bottom flask. Allyldiethylmalonate (22.0 g, 1.1 mol) is added slowly to the reaction mixture with stirring and refluxed for sufficient time to complete hydrolysis. Ethanol is removed with a rotoevaporator. The resultant product is cooled in a beaker and acidified with sulfuric acid. The final solution is extracted with diethylether. The ether layer is collected, dried over MgSO4, and ether is removed with a rotoevaporator. The crude allylmalonic acid is crystalized from petroleum ether.

1. temperaturerefluxed for sufficient time
2. customhydrolysis
3. customEthanol is removed with a rotoevaporator
4. temperatureThe resultant product is cooled in a beaker
5. extractionThe final solution is extracted with diethylether
6. customThe ether layer is collected
7. dry with materialdried over MgSO4, and ether
8. customis removed with a rotoevaporator
9. customThe crude allylmalonic acid is crystalized from petroleum ether