HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 526810Generated: October 26, 2026
Pyrrolidine → 1-[1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-yl]-1-(pyrrolidin-1-yl)-methanimine
https://huagongshe.com/reaction/526810
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Pyrrolidine | HCID 31268 | — |
| Reactant | Citalopram Hydrobromide | HCID 77995 | — |
| Product | 1-[1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-yl]-1-(pyrrolidin-1-yl)-methanimine | HCID 117844268 | 40% |
Reaction Steps
Using 100 mg of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile hydrobromide (citalopram HBr) and pyrrolidine (1.2 equiv) gave, after heating at 80° C. for 14 h, title product (58 mg, 40% yield) as a light yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09346777B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-4349dc7486164fc99f9798f0922aef7b |
|---|
| Source note | uspto-grants-2016_05 |
|---|
