Hydrochloric Acid → HCID 60164157, compound

Participants

Reaction Steps

A 2 M aqueous sodium hydroxide solution (1081 mL) was added (internal temperature: 10 C or lower) to a solution of (S)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate (180 g) in methanol (360 mL) at 5 C over 30 minutes, and the mixture was stirred at room temperature for 1 hour. To the reaction mixture, 1 M hydrochloric acid (2354 mL) was added at 5 C, followed by extraction with ethyl acetate (900 mL×2). The extracts were washed with brine (140 mL) and then dried over anhydrous magnesium sulfate. The solvent was distilled off under reduced pressure to obtain the title compound (166 g).

Provenance & Evidence