反应详情

温度

100 °C

1,4-dioxane (7.5 mL) and manganese (IV) dioxide (447 mg, 5.14 mmol) were added to crude (2,4-dichloro-3-phenylquinolin-6-yl)(3-methylisoxazol-5-yl)methanol (Intermediate 3: step a, 1.03 mmol assuming theoretical yield in prior step). The resulting black suspension was heated in a 100° C. oil bath in a sealed tube for 3 hours then cooled to room temperature. The mixture was then diluted with DCM, and filtered through Celite®. The filtrate was concentrated and the residue was purified by flash column chromatography (silica gel, 3-15% EtOAc-heptane) to afford slightly impure title compound which was used without further purification.

1. customstep a, 1.03 mmol assuming theoretical yield in prior step)
2. temperaturethen cooled to room temperature
3. filtrationfiltered through Celite®
4. concentrationThe filtrate was concentrated
5. customthe residue was purified by flash column chromatography (silica gel, 3-15% EtOAc-heptane)