反应详情

A solution of 5-(4-methylsulfonylbenzyl)-2,2-dimethyl-1,3-dioxane-4,6-dione (1.50 g, 4.80 mmol, Intermediate 6: step a) and 3 M aqueous NaOH (16 mL) was heated in the microwave at 75 W for 20 minutes at 120° C. The aqueous mixture was extracted with EtOAc (1×). The aqueous layer was acidified to pH 1 with concentrated aqueous HCl and extracted with EtOAc (2 x). The combined EtOAc extracts was washed with H2O, brine, dried over Na2SO4, filtered and evaporated to dryness to afford the title compound as a white solid.

1. extractionThe aqueous mixture was extracted with EtOAc (1×)
2. extractionextracted with EtOAc (2 x)
3. washThe combined EtOAc extracts was washed with H2O, brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated to dryness