反应详情

温度

50 °C

To a flask containing (4-chloro-2-methoxy-3-(4-(trifluoromethyl)benzyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol (2.3 g, 4.98 mmol, Intermediate 12: step a) was added 1,4-dioxane (80 mL) to give a suspension at room temperature. The flask was fitted with a reflux condenser and heated briefly to 50° C. which resulted in a homogeneous solution. Then, activated manganese dioxide (1.73 g, 19.9 mmol) was introduced and the temperature was raised to 80° C. After 65 minutes, the reaction mixture was filtered through Celite® and rinsed with warm THF. The effluent was concentrated to dryness to provide the title compound as a white solid.

1. customto give a suspension at room temperature
2. customThe flask was fitted with a reflux condenser
3. customresulted in a homogeneous solution
4. temperaturethe temperature was raised to 80° C
5. filtrationthe reaction mixture was filtered through Celite®
6. washrinsed with warm THF
7. concentrationThe effluent was concentrated to dryness