反应详情

To a solution of tert-butyl (3S)-3-[[2-[5-chloro-1-(p-tolylsulfonyl)pyrrolo[5,4-b]pyridin-3-yl]-5-fluoro-pyrimidin-4-yl]amino]piperidine-1-carboxylate, 1b, (2.1 g, 3.5 mmol) in CH2Cl2 (30 mL) was added trifluoroacetic acid (20 mL). After stirring the reaction mixture at room temperature for 75 min, the mixture was concentrated under vacuo. The crude residue was diluted with EtOAc and neutralized with 1N sodium hydroxide solution. The aqueous phase was separated and extracted again with EtOAc. The combined organic phases were dried (MgSO4), filtered and concentrated under vacuo to afford the desired product (1c) as a light yellow solid.

1. concentrationthe mixture was concentrated under vacuo
2. additionThe crude residue was diluted with EtOAc and neutralized with 1N sodium hydroxide solution
3. customThe aqueous phase was separated
4. extractionextracted again with EtOAc
5. dry with materialThe combined organic phases were dried (MgSO4)
6. filtrationfiltered
7. concentrationconcentrated under vacuo