HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 526889Generated: October 26, 2026
1,4-Dioxane hydrochloride → N-(azetidin-3-yl)-2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-amine hydrochloride
https://huagongshe.com/reaction/526889
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,4-Dioxane hydrochloride | HCID 20443148 | — |
| Reactant | tert-butyl 3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)azetidine-1-carboxylate | HCID 67289632 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-(azetidin-3-yl)-2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-amine hydrochloride | HCID 67284924 | — |
Reaction Steps
A suspension of tert-butyl 3-(2-(5-chloro-1-tosyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)azetidine-1-carboxylate, 6b, (0.23 g, 0.40 mmol) in methanol (10 mL) was treated with 4N HCl/dioxane (5 mL, 20 mmol) then heated at 80° C. for 30 minutes.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09345708B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-f255f77754cc42e096c9ad8dc04e4285 |
|---|
| Source note | uspto-grants-2016_05 |
|---|
