HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-(1-(methylsulfonyl)pyrrolidin-3-yl)pyrimidin-4-amine → HCID 67285972, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-(1-(methylsulfonyl)pyrrolidin-3-yl)pyrimidin-4-amine | HCID 68008525 | — |
| Reactant | HCID 86667414 | HCID 86667414 | — |
| Product | HCID 67285972 | HCID 67285972 | 10% |
Reaction Steps
According to the procedure for compound 398 using 2,5-dioxopyrrolidin-1-yl (tetrahydrofuran-3-yl)methyl carbonate (0.023 g, 0.096 mmol) afforded 5.7 mg (10% yield) of 484, as a trifluoroacetic acid salt after preparatory HPLC purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09345708B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-47001202f8314052b4cae89281346511 |
| Source note | uspto-grants-2016_05 |