HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methyl-3-oxetanecarboxylic Acid → (S)-(3-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)pyrrolidin-1-yl)(3-methyloxetan-3-yl)methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methyl-3-oxetanecarboxylic Acid | HCID 14028997 | — |
| Reactant | (S)-2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoro-N-(1-(methylsulfonyl)pyrrolidin-3-yl)pyrimidin-4-amine | HCID 68008525 | — |
| Product | (S)-(3-(2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-ylamino)pyrrolidin-1-yl)(3-methyloxetan-3-yl)methanone | HCID 68007697 | 42% |
Reaction Steps
According to the procedure for compound 398 using 3-methyloxetane-3-carboxylic acid (15 mg, 0.13 mmol) afforded 17.7 mg (42% yield) of 482, as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09345708B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-41e4aba37ccf41b5b1a5be7eb3f65bca |
| Source note | uspto-grants-2016_05 |