反应详情

To a solution of (7S)-7-(2-chloro-5-fluoropyrimidin-4-ylamino)-2-azaspiro[4.5]decan-3-one, 62d, (0.091 g, 0.159 mmol) in MeOH (2 mL) was added NaOMe (2 mL of 25% w/v, 9.255 mmol). The reaction was stirred for 0.5 hours then concentrated in vacuo. The material was purified by reverse phase HPLC (Water/HCl:MeOH) to give a mixture of diastereomers. The fractions containing pure product were combined and concentrated to give 50 mg of the HCl salt of 969.

1. concentrationthen concentrated in vacuo
2. customThe material was purified by reverse phase HPLC (Water/HCl:MeOH)
3. customto give
4. additiona mixture of diastereomers
5. additionThe fractions containing pure product
6. concentrationconcentrated