Ninhydrin → 1,3-Indandione, 2-(3,5-dimethyl-p-hydroxyphenyl)-2-hydroxy-

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Reaction Steps

Ninhydrin (1.00 g, 5.61 mmol) and 2,6-dimethylphenol (686 mg, 5.61 mmol) was dissolved in acetic acid (15 ml), and this solution was heated for 13 hrs. The reaction mixture was concentrated, and extracted with dichloromethane, and then concentrated organic layer was purified using column chromatography (ethylacetate:hexane=1:2) to afford the title compound (0.31 g, 20%).

Provenance & Evidence