反应详情

N-(2,2-dihydroxy-7-nitro-1,3-dioxo-2,3-dihydro-1H-inden-4-yl)acetamide (0.20 g, 0.71 mmol) and N-(3,4-dimethylphenyl)isobutyramide (136 mg, 0.71 mmol) were dissolved in conc. sulfuric acid (5 mL) and stirred at room temperature for 3 hrs. The reaction mixture was extracted with ethylacetate and ice-water, washed with brine. The washed organic layer dried over sodium sulfate, concentrated in a vacuum, and purified through silica gel column chromatography (30% ethylacetate in hexane) to afford the title compound (30 mg, 10%).

1. extractionThe reaction mixture was extracted with ethylacetate and ice-water
2. washwashed with brine
3. dry with materialThe washed organic layer dried over sodium sulfate
4. concentrationconcentrated in a vacuum
5. custompurified through silica gel column chromatography (30% ethylacetate in hexane)