反应详情

Sodium (1.1 g) was dissolved in anhydrous Ethanol (90 ml). This solution was added with Phthalide (4.43 g, 33.04 mmol) and m-Methoxy benzaldehyde (3.00 g, 22.03 mmol). The reaction mixture was heated for 3 hrs under reflux. The reaction mixture was concentrated in a vacuum. White solid was obtained by adding conc.HCl. And then the white solid was recrystalized in ethylacetate:hexane (=1:2) to afford the title compound (2.45 g, 44%).

1. temperatureThe reaction mixture was heated for 3 hrs
2. temperatureunder reflux
3. concentrationThe reaction mixture was concentrated in a vacuum
4. customWhite solid was obtained
5. additionby adding conc
6. customAnd then the white solid was recrystalized in ethylacetate