Ninhydrin → HCID 90097581, compound

Participants

Reaction Steps

Ninhydrin (1.00 g, 5.6 mmol) was dissolved in conc.H2SO4 (10 ml). This solution was added with N-(3,4-dimethoxyphenyl)isobutyramide (1.25 g, 5.62 mmol) at 0° C. and stirred for 30 min under room temperature. Ice water was added with the reaction mixture, and then washed with ice water and ethylacetate. After drying and filtrating, the ethylacetate layer was purified using column chromatography (ethylacetate:hexane=1:4) to afford the title compound (1.37 g, 63%).

Provenance & Evidence