反应详情

To a solution containing 5 (0.3 g, 0.7 mmol) and hydrazine monohydride (0.19 mL, 3.7 mmol) in 1,4-dioxane. The reaction mixture was stirred and heated to reflux for 4 h. After cooling to room temperature water was added and the mixture was stirred for 30 min. The precipitated solid was filtered and the solid was washed with acetonitrile and then dried under vacuum to obtain the hydrazinecarboxamide intermediate 6 (0.2 g, 82%).

1. temperatureheated
2. temperatureto reflux for 4 h
3. additionwas added
4. stirringthe mixture was stirred for 30 min
5. filtrationThe precipitated solid was filtered
6. washthe solid was washed with acetonitrile
7. customdried under vacuum