Nitrogen → HCID 86698885, compound

Participants

Reaction Steps

In a flame dried round-bottomed flask equipped with a magnetic stir bar and under inert atmosphere (N2), a solution of 1-(2-(hydroxymethyl)oxazol-4-yl)cyclopropyl pivalate (288 mg, 1.20 mmol) at 0° C. in CH2Cl2 (12.0 mL) was treated Et3N (0.22 mL, 1.57 mmol) followed by DMAP (15 mg, 0.12 mmol). Methanesulfonyl chloride (0.11 mL, 1.44 mmol) was then added dropwise and the reaction mixture was stirred for 1 h at rt. Water (5 mL) was added, the layers were separated, and the org. phase was dried over Na2SO4, filtered, and the solvent was removed under reduced pressure to give the title compound as a yellow oil. LC-MS-conditions 06: tR=0.84 min, [M+H]+=318.19.

Provenance & Evidence