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HRID527265

反应详情

EQUATION

反应方程式

HRID 527265 的结构方程式

REACTANTS

反应物

2
结构：CSC(SC)=C(C#N)C(N)=O
HCID2747746

2-cyano-3,3-bis(methylthio)acrylamide

C6H8N2OS2

结构：CC(C)N1CCN(c2ccc(N)cc2)CC1
HCID9161545

4-(4-Isopropylpiperazin-1-yl)aniline

C13H21N3

PRODUCTS

生成物

1
结构：CSC(Nc1ccc(N2CCN(C(C)C)CC2)cc1)=C(C#N)C(N)=O
HCID86701874

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Dissolved 0.500 g 2-cyano-3,3-bis(methylthio)acrylamide in 15 mL EtOH and added 4-(4-(2-propyl)-piperazin-1-yl)aniline (1.0 eq.). Stirred reaction at 75° C. until starting amide was absent by HPLC. Once complete (18 hrs), reaction was brought to room temperature and filtered to obtain 2-cyano-3-((4-(4-isopropylpiperazin-1-yl)phenyl)amino)-3-(methylthio)acrylamide as a purple powder. Product was allowed to dry under vacuum for 1 hr.

WORKUP

后处理

  1. customreaction at 75° C.
  2. customOnce complete (18 hrs), reaction
  3. customwas brought to room temperature
  4. filtrationfiltered