HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 5-Amino-3-(3-chloro-phenylamino)-4-cyano-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 2-(((3-Chlorophenyl)amino)(methylthio)methylene)malononitrile | HCID 14950157 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Amino-3-(3-chloro-phenylamino)-4-cyano-pyrazole | HCID 10681167 | — |
Reaction Steps
Dissolved 2-(((3-chlorophenyl)amino)(methylthio)methylene)malononitrile in EtOH (100 mL) and added and hydrazine hydrate (1 eq., 2.44 mL), then heated to reflux until complete by TLC (absence of starting material, 18 hrs). Poured into ice water and filtered to obtain 5-amino-3-((3-chlorophenyl)amino)-1H-pyrazole-4-carbonitrile as yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346792B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-fbe36d8e4979424580fae56cba88f3a4 |
| Source note | uspto-grants-2016_05 |