Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | HCID 86701897 | HCID 86701897 | — |
| Product | HCID 86701896 | HCID 86701896 | — |
Reaction Steps
3-((3-amino-2-cyano-1-(methylthio)-3-oxoprop-1-en-1-yl)amino)benzoic acid was then suspended in 10 mL EtOH and hydrazine hydrate (124 μL, 1.0 eq.) was added dropwise. Reaction was heated at 75° C. until intermediate was absent (HPLC). Once intermediate was absent (18 hrs), reaction was brought to room temperature and filtered to obtain 4-((5-amino-4-carbamoyl-1H-pyrazol-3-yl)amino)benzoic acid as a yellow powder. Product was allowed to dry under vacuum for 1 hr.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09346792B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-95bd0d63b7c34d029ec658ea12006ff1 |
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| Source note | uspto-grants-2016_05 |
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