2-(4-(N-cyano-S-methylsulfonimidoyl)benzyl)isoindoline-1,3-dione → 2-(4-(N-cyano-S-ethylsulfonimidoyl)benzyl)isoindoline-1,3-dione

HRID 527346Notes

Reaction equation

HRID 527346 reaction equation
[C:1]([N:3]=[S:4]([C:7]1[CH:24]=[CH:23][C:10]([CH2:11][N:12]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:22])=[CH:9][CH:8]=1)([CH3:6])=[O:5])#[N:2].[C:25](N=S(C1C=CC(CN2C(=O)C3C(=CC=CC=3)C2=O)=CC=1)CC)#N>>[C:1]([N:3]=[S:4]([C:7]1[CH:24]=[CH:23][C:10]([CH2:11][N:12]2[C:20](=[O:21])[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]2=[O:22])=[CH:9][CH:8]=1)([CH2:6][CH3:25])=[O:5])#[N:2]

Participants

3

Reactant 2

HCID 867116102-(4-(N-cyano-S-methylsulfonimidoyl)benzyl)isoindoline-1,3-dioneHCID 867116152-(4-(N-cyano-S-ethylsulfinimidoyl)benzyl)isoindoline-1,3-dione

Product 1

HCID 867116162-(4-(N-cyano-S-ethylsulfonimidoyl)benzyl)isoindoline-1,3-dione

Procedure

The title compound is prepared in analogy to preparation 6c, substituting 2-(4-(N-cyano-S-methylsulfinimidoyl)benzyl)isoindoline-1,3-dione with 2-(4-(N-cyano-S-ethylsulfinimidoyl)benzyl)isoindoline-1,3-dione (preparation 13a). ESI mass spectrum: [M+H]+=354; r.t. HPLC: 3.33 min (LCMS-FA-8).

Workup

  1. customr.t
  2. custom3.33 min (LCMS-FA-8)

Sources & evidence

ORD record
ord-8f881966adca4ed6bd58ecb1bbc446ed
Source dataset
uspto-grants-2016_05
Patent number
US09346794B1

Reaction notes

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