Acetic Acid → HCID 86711622, compound

Participants

Reaction Steps

2-(3-Fluoro-4-(N-cyano-S-methylsulfinimidoyl)-benzyl)-isoindole-1,3-dione (preparation 15b, 1.60 g, 4.22 mmol) and acetic acid (0.25 g, 4.22 mmol) are added to a solution of potassium permanganate (670 mg, 4.22 mmol) in a mixture of water (8 mL) and acetonitrile (9.6 ml). The mixture is stirred over night, and saturated aqueous Na2S2O3 solution is added. The mixture is extracted with ethyl acetate and the organic layer is dried over Na2SO4. The residue is directly used in the next step without further purification. Yield: 1.34 g (80% of theory); ESI mass spectrum: [M+H]+=358; r.t. HPLC: 0.73 min (5-95AB).

Provenance & Evidence