Dichloromethane → HCID 86711623, compound

Participants

Reaction Steps

Hydrazine (85% in water, 2.0 g, 53 mmol) is added to a solution of 2-(3-fluoro-4-(N-cyano-S-methylsulfonimidoyl)-benzyl)-isoindole-1,3-dione (preparation 15c, 3.5 g, 8.8 mmol) in a 1:1 mixture of dichloromethane and methanol (140 mL). The mixture is stirred over night and concentrated under reduced pressure. The residue is purified by preparative reversed phase HPLC (Luna C18(2), gradient of acetonitrile in water, 0.01 M NH3). Yield: 1.2 g (58% of theory); ESI mass spectrum: [M+H]+=228; r.t. HPLC: 0.26 min (X011_S03).

Provenance & Evidence