Potassium Carbonate → 2-(4-(S-Methylsulfonimidoyl)benzyl)isoindoline-1,3-dione

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Reaction Steps

Potassium carbonate (3.37 g, 24.4 mmol) is added to a solution of 2-(4-(N-trifluoracetyl-S-methylsulfonimidoyl)benzyl)isoindoline-1,3-dione (preparation 17a, 2.00 g, 4.88 mmol) in methanol (20 mL). The mixture is stirred at room temperature for 16 h and filtered. The filtrate is concentrated under reduced pressure, and the residue is purified by flash chromatography on silica (methanol/dichloromethane 7:3). Yield: 0.90 g (58% of theory); ESI mass spectrum: [M+H]+=315, r.t. HPLC: 1.08 min (V003_003).

Provenance & Evidence