Potassium Carbonate → HCID 86711637, compound

Participants

Reaction Steps

A mixture of 1-isopropyl-6-methyl-4-oxo-5-(3-trifluoromethyl-phenyl)-1,4-dihydro-pyridine-3-carboxylic acid 4-(S-cyclopropyl-N-cyanosulfinimidoyl)-benzylamide (preparation 63d, 40 mg, 74 μmol), meta-chloroperoxybenzoic acid (77%, 25 mg, 0.11 mmol) and potassium carbonate (31 mg, 0.22 mmol) in ethanol is stirred at room temperature for 1 h. Another portion of meta-chloroperoxybenzoic acid (77%, 5 mg, ai 0.02 mmol) is added and stirring is continued for 1.5 h. Saturated aqueous sodium thiosulfate solution is added, and the mixture is extracted with dichloromethane. The organic layer is dried over Na2SO4 and concentrated under reduced pressure. The residue is purified by preparative reversed phase HPLC (Xbridge, gradient of acetonitrile in water, 0.1% TFA). Yield: 13 mg (31% of theory); ESI mass spectrum: [M+H]+=557; r.t. HPLC: 0.65 min (X011_S03).

Provenance & Evidence