反应详情

温度

100 °C

A mixture of 2-(4-(S-methylsulfonimidoyl)benzyl)isoindoline-1,3-dione (preparation 17b, 200 mg, 63.6 mmol) and paraformaldehyde (115 mg, 1.27 mmol) in acetic acid (2 mL) is heated in a microwave at 100° C. for 4 h. The mixture is concentrated under reduced pressure, and the residue is purified by flash chromatography on silica (gradient dichloromethane to dichloromethane/methanol 95:5). Yield: 189 mg (90% of theory); ESI mass spectrum: [M+H]+=329; r.t. HPLC: 0.45 min (X011_S03).

1. concentrationThe mixture is concentrated under reduced pressure
2. customthe residue is purified by flash chromatography on silica (gradient dichloromethane to dichloromethane/methanol 95:5)
3. customr.t
4. custom0.45 min (X011_S03)