HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → HCID 57477135, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 3-Pyridinecarbonyl chloride, hydrochloride (1:1) | HCID 88438 | — |
| Reactant | tert-butyl (3S)-3-aminopyrrolidine-1-carboxylate | HCID 854071 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 57477135 | HCID 57477135 | 97.4% |
Reaction Steps
Nicotinoyl chloride hydrochloride (286 mg, 1.61 mmol, 1.0 eq) was added at room temperature to a stirred solution of (S)-3-amino-1-N-BOC-pyrrolidine (300 mg, 1.61 mmol, 1.0 eq) in CH2Cl2 (9 mL), followed by triethylamine (337 μL, 2.42 mmol, 1.5 eq). After stirring overnight at room temperature, the reaction mixture was extracted and the organic layer was dried over Na2SO4, filtered and evaporated to afford 457 mg of the expected compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09346799B2 |
| Source dataset | uspto-grants-2016_05 |
| ORD ID | ord-76ff9dd432054f958b8127280f97d0de |
| Source note | uspto-grants-2016_05 |