2-Chloro-4-(4-methylpiperazin-1-yl)aniline → N-(3-(2-((2-chloro-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide

Participants

Role	Name	HCID	Charge
Reactant	2-Chloro-4-(4-methylpiperazin-1-yl)aniline	HCID 57416094	—
Reactant	tert-Butyl (3-(2-((2-chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate	HCID 86732035	—
Product	N-(3-(2-((2-chloro-4-(4-methyl-1-piperazinyl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)-2-propenamide	HCID 78318939	—

Reaction Steps

The title compound was prepared according to the procedures described for Example 1, starting from 2-chloro-4-(4-methylpiperazin-1-yl)aniline (Aurum Pharmatech LLC, Wowell, N.J.). tert-Butyl (3-(2-((2-chloro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7-oxopyrido[2,3-d]pyrimidin-8(7H)-yl)phenyl)carbamate (15a): m/z (ESI, +ve ion) 562.0 (M+H)+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09346801B2
Source dataset	uspto-grants-2016_05
ORD ID	ord-6f2c82b26baa447095d3009e341a0a77
Source note	uspto-grants-2016_05