Acetaldehyde → HCID 58312634, compound

Participants

Reaction Steps

In analogy to the procedure described for the synthesis of rac-{(3S,4R)-4-(3,4-Dichloro-phenyl)-1-[1-(1-methyl-cyclopropanecarbonyl)-piperidine-4-carbonyl]-pyrrolidin-3-yl}-ethyl-carbamic acid 4-fluoro-phenyl ester (example 1, step g & h) the title compound was prepared from (3S,4R)-1-Benzyl-4-(4-chloro-3-fluoro-phenyl)-pyrrolidin-3-ylamine through reductive amination with acetaldehyde followed by reaction with 4-fluorophenyl chloroformate to yield the title compound as light brown oil. MS m/e: 471.2 [M+H]+.

Provenance & Evidence