Acetic Anhydride → 1-(2,6-dihydroxy-4-methylphenyl)ethanone O-acetyloxime

HRID 527518Notes

Reaction equation

HRID 527518 reaction equation
[OH:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([OH:9])[C:3]=1[C:10](=[N:12][OH:13])[CH3:11].[C:14](OC(=O)C)(=[O:16])[CH3:15]>>[C:14]([O:13][N:12]=[C:10]([C:3]1[C:4]([OH:9])=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=1[OH:1])[CH3:11])(=[O:16])[CH3:15]

Participants

3

Reactant 2

HCID 7918Acetic AnhydrideHCID 1363786481-(2,6-Dihydroxy-4-methylphenyl)ethanone oxime2×

Product 1

HCID 1363786491-(2,6-dihydroxy-4-methylphenyl)ethanone O-acetyloxime

Procedure

To 1-(2,6-dihydroxy-4-methylphenyl)ethanone oxime (Intermediate 17, 829 mg), acetic anhydride (2.6 ml, 27.5 mmol) was added and the reaction mixture was stirred at room temperature for 1 hour. After the removal of the volatiles, the residue was washed with water, filtered and dried. This afforded 1.0 g of the title compound.

Workup

  1. customAfter the removal of the volatiles
  2. washthe residue was washed with water
  3. filtrationfiltered
  4. customdried

Sources & evidence

ORD record
ord-053aa48ead4d428a852555d7620b7ec1
Source dataset
uspto-grants-2016_05
Patent number
US09346790B2

Reaction notes

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