Stannous chloride dihydrate → 6-[(3-Ethyl-1,2-benzisoxazol-4-yl)oxy]-3-pyridinamine

Participants

Reaction Conditions

Reaction Steps

3-ethyl-4-[(5-nitro-2-pyridinyl)oxy]-1,2-benzisoxazole (Intermediate 32, 9 mg) was dissolved in 3.0 ml of ethanol. Then tin(II) chloride dihydrate (21.4 mg, 0.095 mmol) was added and the reaction mixture was stirred at 80° C. for 3 hours. After quenching with water and extraction with ethyl acetate, the organic phase was dried over sodium sulphate, filtered and evaporated to afford the title compound.

Provenance & Evidence