反应详情

1-(2,6-dihydroxyphenyl)-2-methyl-1-propanone oxime (Intermediate 38, 320 mg) was stirred in acetic anhydride (0.928 ml, 9.84 mmol) at room temperature for 1 hour. After removal of the volatiles, the crude was washed with water, filtered and dried. The residue obtained was charged on a silica gel column (Biotage SP1 system) and eluted with Cyhexane/ethyl acetate (from 100/0 to 0/100) to afford the title compound (127 mg).

1. customAfter removal of the volatiles
2. washthe crude was washed with water
3. filtrationfiltered
4. customdried
5. customThe residue obtained
6. additionwas charged on a silica gel column (Biotage SP1 system)
7. washeluted with Cyhexane/ethyl acetate (from 100/0 to 0/100)