1-Aminocyclopropane-1-carboxylic acid → 1-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid

HRID 527557Notes

Reaction equation

HRID 527557 reaction equation
[CH3:1][C:2]([O:5][C:6]([NH:8][C:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]C1)=[O:7])([CH3:4])[CH3:3].NC1(C(O)=O)CCC1.NC1(C(O)=O)CC1>>[CH3:4][C:2]([O:5][C:6]([NH:8][C:9]1([C:13]([OH:15])=[O:14])[CH2:12][CH2:11]1)=[O:7])([CH3:1])[CH3:3]

Participants

4

Reactant 3

HCID 5351-Aminocyclopropane-1-carboxylic acidHCID 896431-Aminocyclobutanecarboxylic acidHCID 1512646Cyclobutanecarboxylic acid, 1-(((1,1-dimethylethoxy)carbonyl)amino)-

Product 1

HCID 6883961-((tert-Butoxycarbonyl)amino)cyclopropanecarboxylic acid

Procedure

The title compound (998 mg) was made in a similar fashion to the preparation of Intermediate 68 replacing 1-aminocyclobutanecarboxylic acid WITH 1-aminocyclopropanecarboxylic acid (550 mg).

Sources & evidence

ORD record
ord-4f63fdf828c345bfb05ef72842abfcf3
Source dataset
uspto-grants-2016_05
Patent number
US09346790B2

Reaction notes

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