反应详情

To a solution of 1,1-dimethylethyl {(1R)-1-[({2-[(3,3-dimethyl-2,3-dihydro-1-benzofuran-4-yl)oxy]-5-pyrimidinyl}amino)carbonyl]-2,2-dimethylpropyl}carbamate (Intermediate 77, 13 mg) in dry dichloromethane (0.5 ml) cooled to 0° C., TFA (85 μl, 1.105 mmol) was added dropwise and the solution was stirred for 3 hours at that temperature. The volatiles were evaporated. The residue was dissolved with dichloromethane (2 ml) and an aqueous saturated solution of NaHCO3 was added (4 ml). The layers were separated and the aqueous layer was extracted twice with dichloromethane. The gathered organic layers were dried over sodium sulphate and evaporated to afford the title compound (10.9 mg).

1. customThe volatiles were evaporated
2. dissolutionThe residue was dissolved with dichloromethane (2 ml)
3. additionan aqueous saturated solution of NaHCO3 was added (4 ml)
4. customThe layers were separated
5. extractionthe aqueous layer was extracted twice with dichloromethane
6. dry with materialThe gathered organic layers were dried over sodium sulphate
7. customevaporated