Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-5-nitropyridine | HCID 78308 | — |
| Reactant | 4-hydroxy-3-(trifluoromethyl)benzonitrile | HCID 2783159 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 67236621 | HCID 67236621 | 62.5% |
Reaction Steps
A mixture of 2-chloro-5-nitropyridine (70 mg, 0.44 mmol), 4-hydroxy-3-(trifluoromethyl)benzonitrile (91 mg, 0.49 mmol), K2CO3 (92 mg, 0.66 mmol) in DMF (2 mL) was stirred at 50° C. overnight. Water (4 mL) was added and a precipitate was formed. The solid was filtered-off and it was triturated with MeOH to give the title compound (85 mg) as a brownish solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09346790B2 |
|---|
| Source dataset | uspto-grants-2016_05 |
|---|
| ORD ID | ord-d91dbdf59f924de3864d938620f9f461 |
|---|
| Source note | uspto-grants-2016_05 |
|---|
