Lithium Hydroxide → HCID 89930856, compound

Participants

Reaction Steps

A solution of methyl 4-((4-((S)-2-((S)-2-((tert-butoxycarbonyl)(methyl)amino)propanamido)-3-((R)-3,3-dimethyl-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,3-azasilolidin-1-yl)-3-oxopropyl)phenyl)carbamoyl)benzoate (160 mg, 0.200 mmol) and LiOH (300 mg) in MeOH (6 mL) and H2O (2 mL) was stirred at rt for 2.5 h. Most of the MeOH was removed in vacuo and the residue was mixed with EtOAc and 1N HCl (60 mL). The organic layer was separated, dried over MgSO4 and concentrated in vacuo to obtain the title compound (140 mg, 0.179 mmol, 71% yield) as a white solid. MS(ESI+) m/z 784.4 (M+H)+.

Provenance & Evidence