Trifluoroacetic acid → HCID 89930805, compound

Participants

Reaction Steps

To a solution of tert-butyl 4-((S)-2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-3-((R)-3,3-dimethyl-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,3-azasilolidin-1-yl)-3-oxopropyl)benzoate (0.17 g, 0.22 mmol) in CH2Cl2 (10 mL) was added TFA (1 mL) at rt. After 4 h, the reaction mixture was concentrated in vacuo to obtain the title compound (150 mg, 82% yield) as a white solid. 1H NMR (400 MHz, CDCl3) δ 12.37 (br. s., 1H), 8.05 (d, J=8.4 Hz, 2H), 7.76 (d, J=7.5 Hz, 2H), 7.56 (dd, J=7.3, 4.4 Hz, 2H), 7.44-7.05 (m, 11H), 6.62-6.52 (m, 2H), 5.23-5.09 (m, 2H), 4.94 (t, J=6.9 Hz, 1H), 4.38-4.11 (m, 3H), 3.33 (d, J=13.2 Hz, 1H), 3.20 (dd, J=14.1, 4.8 Hz, 1H), 3.03-2.93 (m, 2H), 2.86-2.74 (m, 2H), 2.11-2.01 (m, 1H), 1.92-1.79 (m, 3H), 1.27 (d, J=6.6 Hz, 2H), 0.45 (s, 3H), 0.32 (s, 3H); MS(ESI+) m/z 702.1 (M+H)+.

Provenance & Evidence