Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of methyl 4-((4-((S)-2-((tert-butoxycarbonyl)amino)-3-((R)-3,3-dimethyl-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,3-azasilolidin-1-yl)-3-oxopropyl)phenyl)ethynyl)benzoate (92 mg, 0.13 mmol) in DCM (2 mL) was added HCl (4.0 M solution in dioxane, 0.5 mL, 2.00 mmol). The reaction mixture was stirred at rt for 4 h and concentrated in vacuo to give the title compound as a HCl salt (80 mg, 95%, brown solid). MS(ESI+) m/z 594.5 (M+H)+.

Provenance & Evidence