Hydrochloric Acid → Hydrochloric Acid

Participants

Reaction Steps

To a solution of methyl 4′-((S)-2-((tert-butoxycarbonyl)amino)-3-((R)-3,3-dimethyl-5-(((R)-1,2,3,4-tetrahydronaphthalen-1-yl)carbamoyl)-1,3-azasilolidin-1-yl)-3-oxopropyl)-[1,1′-biphenyl]-4-carboxylate (30 mg, 0.045 mmol) in DCM (2 mL) was added HCl (4.0 M solution in dioxane) (0.34 mL, 1.34 mmol). The reaction mixture was stirred at rt for 3 h. The reaction mixture was concentrated in vacuo to give the title compound HCl salt as a light yellow solid (25 mg, 92%). MS(ESI+) m/z 570.5 (M+H)+.

Provenance & Evidence